The role of neuroendocrine cells in prostate cancer. A reappraisal of the current literature and a subsequent rationale to expand and integrate the current treatment modalities

3 March 2017
The role of neuroendocrine cells in prostate cancer. A reappraisal of the current literature and a subsequent rationale to expand and integrate the current treatment modalities

Prostate cancer is the most common solid tumor in Europe and 95% of cases is a acinar adenocarcinoma.
Because of the dubious origin of these cells, it is difficult to establish a “gold standard” treatment.
By consulting many publications on this topic, the surgery, radiotherapy, the ablative techniques, the immuno-modulation and the epigenetic therapy were evaluated.
For the ablation there are modern techniques such as:

high intensity ultrasound;
sensitizing rays of gold light with particular wavelengths;
cryosurgery that freezes the tumor
epigenetic therapy that is a new field of research not yet very well known to the operators.

It is suggested to add to all the ablative therapies the treatment with factors of differentiation of stem cells that stop the maturation toward the malignancy of cells that can give rise to the tumor.

 

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